Hydrazide derivative of Cyanine7, a NIR fluorescent dye, an analog of Cy7®.
This variety of heptamethine fluorophore contains a six-membered ring rigidizing the polymethine chain which allows to increase quantum yield by 20% compared to parent structure.
Hydrazide reacts quickly and smoothly with aldehydes and ketones yielding stable hydrazone products. This reaction is also good for the labeling of glycoproteins after periodate oxidation.
Cy® is a trademark of GE Healthcare.
General properties
Appearance:
green powder
Mass spec M+ increment:
544.8
Molecular weight:
635.70
Molecular formula:
C37H48Cl2N4O
Solubility:
moderate solubility in water, good in polar organic solvents (DMF, DMSO, alcohols)
Quality control:
NMR 1H, HPLC-MS (95%)
Storage conditions:
Storage: 24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate.
Spectral properties
Excitation maximum, nm:
750
ε, L⋅mol−1⋅cm−1:
199000
Emission maximum, nm:
773
Fluorescence quantum yield:
0.3
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